Supplements should have some immediate positive effects. Unless supplements have immediate positive effects there is no way to know whether supplements are taking individuals in the right direction. Taking supplements to prevent diseases of aging is a poor strategy for healthy longevity. There are so many ways to go wrong with supplements that stumbling on a longevity supplement regime that really works is very unlikely, however, if supplements have immediate beneficial effects then one knows one is going the right direction. Taking supplements as preventive medicine is a fail as strategy for taking supplements. Balanced meals, watching the weight and exercise are the best preventive medicine all of which have immediate positive benefits.