The Central Dogma of Biology – Information passes from DNA to proteins via RNA, but proteins cannot pass the information back to DNA.
Changes in enzyme activities can result in various epigenetic changes so while DNA sequences are not altered by enzyme activities and/or enzyme levels transcription and/or translation of genes can be altered by changes in enzyme activities and enzyme levels by genes becoming methylated. Epigenetics is not subject to the Central Dogma whereby enzyme activities and enzyme levels can affect methylation of gametes. There still has to be a mechanism whereby embryos are not completely stripped of methyl marks for there to be transgenerational epigenetic inheritance. Dysregulation of TET enzymes that demethylate DNA in embryos could leave a path open for transgenerational epigenetic inheritances.
