Pantothenic acid and iron-sulfur cluster formation

Supplemental pantothenic acid increases levels of fatty acid synthase and the acyl carrier protein. Pantothenic acid donates a 4′-phosphopantetheine moiety to the acyl carrier protein. The mitochondrial acyl carrier protein (ACP) of fatty acid synthase is required for iron-sulfur cluster biogenesis.

Supplemental pantothenic acid is then of assistance both in increasing activity of the citric acid cycle and of assistance in increasing iron-sulfur cluster biogenesis.

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