Coenzyme A could be a very useful supplement. Pantothenic acid is supplemented to increase coenzyme A levels. Supplementing with coenzyme A would directly increase coenzyme A levels. There are supplements labeled as coenzyme A that do not contain any coenzyme A. For example Coenyzme-A Technologies has a supplement labeled as Pure Coenzyme A that contains no coenzyme A where the actual ingredients of the product are ingredients that should not be supplemented. Apparently there are no supplements on the market that contain coenzyme A. There may be a reason why coenzyme A is not sold as a supplement but I have seen medical journal articles where coenzyme A was prescribed for patients. Coenzyme A should not be confused with coenzyme Q10 or with vitamin A.
Sulbutiamine and biotin would still have to be supplemented even given coenzyme A were supplemented.