α7 nicotinic acetylcholine receptor and schizophrenia

In this Youtube video Dr. Robert Freedman talks about the α7 nicotinic receptor, which is agonized by acetylcholine,  and schizophrenia.  Dr. Freedman stresses choline shortages especially in the fetus. Choline is required for the synthesis of acetylcholine. I think there are terrific difficulties with acetylcholine in schizophrenia but the difficulty arises from difficulties in the synthesis of acetyl-coenzyme A which is required for the synthesis of acetylcholine. Acetyl-coenzyme A synthesis is dysregulated in schizophrenia do to dysregulations in schizophrenia of the pyruvate dehydrogenase complex of the citric acid cycle.

 

 

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