Inhibition of non-heme iron absorption in humans by drinks containing polyphenols

Polyphenol containing drinks are potent inhibitors of Fe absorption and reduce absorption of iron in a dose-dependent fashion depending on polyphenols contents of drinks.

The difficulty with polyphenol containing beverages is more severe than only decreased iron absorption as iron in the gut also regulates the citric acid cycle in the gut. Polyphenol compounds form complexes with iron whereby aconitase 1, which is regulated by iron, in the gut can become dysregulated when drinks with polyphenol compounds are drunk.

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