Inhibition of non-heme iron absorption in humans by drinks containing phenols

Phenol containing drinks are potent inhibitors of Fe absorption and reduce absorption of iron in a dose-dependent fashion depending on polyphenols contents of drinks.

The difficulty with phenol containing beverages is more severe than only decreased iron absorption as iron in the gut also regulates the citric acid cycle in the gut. Phenol compounds form complexes with iron whereby aconitase 1, which is regulated by iron, in the gut can become dysregulated when drinks with phenol compounds are drunk.

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