The C282Y HFE mutation and Alzheimer’s

The C282Y HFE gene mutation is associated with iron overload. The C282Y HFE mutation is, however, protective against Alzheimer’s disease. Serum iron levels are negatively associated with the risk for Alzheimer’s disease. Though iron plays a role in Alzheimer’s disease the equation increased ‘iron levels = increased risk for Alzheimer’s disease’ does not fit research findings.

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