There is lots and lots of research on how to increase absorption of minerals. The supplement industry following up on this has formulated mineral supplements to be better absorbed.
My idea that minerals must be available both in the enteric system and systematically to be useful in treating illnesses does not conflict with any biological findings but it goes against what is held as common sense. Every one just knows that the goal with mineral supplements is to increase and enhance absorption. Minerals that are not formulated for increased abosorption can be absorbed and can effectively treat diseases associated with mineral deficiencies. Most of the clinical trials of minerals do not use amino acid chelates.
The assumption with minerals formulated for increased absorption is that somehow proteins in the enteric system watch minerals pass by unused and hold that is totally acceptable. Proteins in the enteric system are willing to go the end of the line and wait for minerals to get back to them. The common sense idea is that the gastrointestinal tract is like a busy 4 way intersection.
Metal proteins in the enteric system could set the stage for metal proteins throughout the body. Systematically metal proteins might not work effectively unless the stage is set by metal proteins in the enteric system working.