Genetics of schizophrenia has become uninteresting

The following paragraph is from From Schizophrenia in 2020: Trends in diagnosis and therapy by Wolfgang Gaebel  and  Jürgen Zielasek

“The number of risk‐associated loci in schizophrenia is estimated to be at about 850 loci. All of these genetic risk markers may explain around 10% of all schizophrenia cases. Some rare copy number variations, especially those involving partial deletions of the long arm of chromosome 22 (22q11.2), show a high penetrance in schizophrenia, but these cases only amount to approximately 0.2–0.3% of all patients with schizophrenia. Genome‐wide association studies in schizophrenia have added new risk loci and recently increased the number of probably relevant genetic polymorphisms into the range of n = 8500, but also increasing the explained variance of liability to about 32%.”

Genetics of schizophrenia has become uninteresting.

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.