“The number of risk‐associated loci in schizophrenia is estimated to be at about 850 loci. All of these genetic risk markers may explain around 10% of all schizophrenia cases. Some rare copy number variations, especially those involving partial deletions of the long arm of chromosome 22 (22q11.2), show a high penetrance in schizophrenia, but these cases only amount to approximately 0.2–0.3% of all patients with schizophrenia. Genome‐wide association studies in schizophrenia have added new risk loci and recently increased the number of probably relevant genetic polymorphisms into the range of n = 8500, but also increasing the explained variance of liability to about 32%.”
Genetics of schizophrenia has become boring.