I have been arguing on this blog that supplements have to be available in the gastrointestinal tract as well as systematically for supplements to be helpful. There has been a growing realization that what happens in the gut can have a huge impact on mental health. See these reviews – Microbes and mental health: A review; Harnessing Gut Microbes for Mental Health: Getting From Here to There and Brain-Gut-Microbiota Axis and Mental Health.
If supplements are not available in the gastrointestinal tract this cannot but affect gut microbiota differently compared to supplements that are available in the gastrointestinal tract. I am open to the possibility that differences in gut microbiota can play a big role in mental states, however, the gut could also be set up so the gut has to use nutrients when nutients first pass through the gut. Use of nutrients by the gut could be a necessary first step in the use of nutrients systematically.
There is a lot of talk about how the diet of our very distant ancestors is the diet that is appropriate for us. One thing is certain about the diet of our very distant ancestors. Our very distant ancestors did not take nutrients than were formulated not to be available in the gut.