Dysregulations of intracellular calcium are thought to play a role in autism. Taurine regulates intracellular calcium in neurons. A subgroup of children with autistic spectrum disorders, 21 out of 66, had low taurine concentrations (<106 μM).
Children with autism had lower serum 25(OH)D (a metabolite of vitamin D) concentrations than did control subjects (19 vs. 33 ng/ml), despite parents of each group reporting the same amount of sun exposure. Taurine conjugated to bile acids assists in the absorption of fat-soluble vitamins. Vitamin D is a fat-soluble vitamin. Vitamin K is fat-soluble vitamin involved in bone formation via osteocalcin. Vitamin K deficiencies could co-occur with vitamin D deficiencies as in both cases there could be a failure to absorb fat-soluble vitamins due to deficiencies in taurine.
Dysregulations of taurine could play a key role in the development of autism. A treatment for autism could look a lot like a treatment for osteoporosis. Taurine, vitamin D3, vitamin K2 MK-7, which is better absorbed than other forms of vitamin K, and calcium from calcium carbonate could be helpful in a subgroup of children with autism who also have low taurine levels. No studies of taurine, vitamin D3, vitamin K (MK-7) and calcium from calcium carbonate in the treatment of autism have yet been done.