Bipolar depression is due to dysregulation of the sodium-dependent multivitamin transporter. See the page on bipolar depression. Biotin and pantothenic acid, which supposedly no one has deficiencies of unless one spends a couple of years in a concentration camp, can become deficient given the SMVT is dysregulated. Biotin is required for fatty acid synthesis. Even with biotin supplemented non-essential fatty acids are not being synthesized. MCT oil contains medium chain fatty acids that are synthesized right after the biotin-dependent acetyl-CoA carboxylase step. MCT oil is a useful supplement. .There is clearly a difference between MCT oil which is all caprylic acid and MCT oil which is a mixture of caprylic acid and capric acid. Only MCT oi which is a mixture of .caprylic acid and capric acid works.
The SMVT also transports iodide. Iodide from potassium iodine must by supplemented. With the SMVT dysregulated iodide must be transported by SLC5A5 which is strongly expressed in the stomach but not in the rest of the gut. Iodine from kelp would not be available in the stomach. Thyroid tests can be normal and still iodine from potassium iodine must still be supplemented.
Pantothenic kinase is the rate limiting step in the synthesis of coenzyme A. Pantothenic acid regulates pantothenic kinase.
Biotin-containing enzymes require bicarbonate. Sodium bicarbonate could be helpful.
Biotin, pantothenic acid, MCT oil, sodium bicarbonate, taurine and branched-chain amino acids are taken three times a day. Iodide from potassium iodide is taken once a day. Sodium bicarbonate contains sodium so blood pressure must be watched. Individuals with high blood pressure may not be able to take sodium bicarbonate..The MCT oil should be a mixture of caprylic acid and capric acid.
Lithium blocks the SMVT. Lithium is apparently ‘effective’ via generating biotin and pantothenic acid deficiencies. Biotin and pantothenic acid deficiencies would be expected given individuals are on therapeutic dosages of lithium. John Cade discovered how to treat mania via generating biotin and pantothenic deficiencies. Not a big win for serendipity.
Hypomania – good. Mania – bad. This could result in hypomania or mania. Mania is most definitely to be avoided. As I have said lots of places on this blog 600 mg of carbonyl iron taken at bedtime is a treatment for psychosis. The proposed treatment could result in mania. Elsewhere on this blog I have argued that 600 mg of carbonyl iron taken at bedtime can treat psychosis. 200 micrograms of Se-methylselenocysteine is useful for disorganization.
Clearly the proposed treatment is a lot and would not be started unless biotin, pantothenic acid and/or coenzyme A levels are found to be low in individuals with bipolar depressions who are not taking lithium and/or anticonvulsants. As the treatment could interfere with the actions of lithium and/or anticonvulsants the proposed treatment would not be tried by individuals who are on lithium and/or anticonvulsants. Biotin, pantothenic acid and coenzyme A levels, however, should be checked in individuals who are are on lithium and/or anticonvulsants .