Supposedly individuals with schizophrenia have low IQ’s. However, low IQ’s of individuals with schizophrenia could be a reflection of a treatable disorganization. Doing well on IQ tests is very difficult when disorganized. Supplementation with Se-methylselenocysteine treats disorganization and cognitive symptoms in schizophrenia. With supplementation with Se-methylselenocysteine IQ’s of individuals with schizophrenia could be increased. Supplementation with more than 200 micrograms of selenium a day should be avoided.
With the transsulfuration pathway dysregulated homocysteine levels can be increased and L-selenomethioinine, the food form of selenium, not metabolized. L-seleomethionine is metabolized by cystathionine gamma-lyase (CTH) which is an an enzyme in the transsulfuration pathway. Supplementation with Se-methylselenocysteine could be particularly effective in raising IQ’s in individuals with schizophrenia who have high homocysteine levels which would indicate that .L-selenomethioinine is not being metabolized adversely affected selenoprotein levels,.
Why would Se-methylselenocysteine be effective in treating disorganization? Selenoproteins are very frequently antioxidant proteins. With lots of free radicals bouncing around thoughts bounce around which presents as disorganization and as cognitive symptoms. Se-methylselenocysteine can stop lots of free radicals from bouncing around stopping thoughts from bouncing around treating disorganization and cognitive symptoms and perhaps raising IQ’s in individuals with schizophrenia.