The sodium-dependent multivitamin transporter transports pantothenic acid, biotin, lipoate and iodide. The sodium iodide symporter (NIS) is the key iodide transporter on the thyroid, however, the SMVT apparently has a key role in gut absorption of iodide. Pantothenic acid, biotin and iodide can have countervailing effects on each other. Perhaps the evolutionary goal is euthymic states combined with some environmental control, however, in terms of delivering euthymic states the SMVT is a complete fail is all too many instances.
Genes in the gut for the SMVT are in all probability hypermethylated. Environmental factors could lead to the hypemethylation of genes for the SMVT in the gastrointestinal tract..Hypermethylation of genes in the gut is the first place to look for genes that are hypermethylated due to environmental factors as the gut has the greatest exposure to environmental factors.
Biotin is synthesized by gut microorganisms. Changes is gut microorganisms could lead to decreases in biotin synthesis adversely affecting energy levels. Pantothenic acid is also synthesized by gut microorganisms. Changes is gut microorganisms could lead to decreases in pantothenic acid synthesis by gut microorganisms. Addressing dysregulation of the SMVT is not a simple, straightforward operation.