Transient receptor potential melastatin 7 (TRPM7) is an ion channel that increases intracellular calcium levels. TRPM7 is inhibited by magnesium, however, when TRP7 complexes with transient receptor potential melastatin 6 (TRPM6) TRPM7 is insensitive to inhibition by magnesium. A magnesium-enriched diet upregulates messenger RNA of TRPM6 in the colon. Even though TRPM7 in inhibited by magnesium a magnesium enriched diet would not decrease absorption of calcium from the gut as TRPPM6 and TRPM6/7 complexes are not inhibited by magnesium. TRPM6 is highly expressed in the gut. Mutations in TRPM6 are associated with hypomagnesia with secondary hypocalcemia
Magnesium in the gut could have a large effect on calcium absorption in the gut. . Rather than calcium supplementation magnesium oxide supplementation could be the way to address osteoporosis with a mineral. Calcium supplements available in the gut taken with magnesium oxide could result in hypercalcemia marked by spaced out feelings. Supplementing with too much magnesium oxide even when taken without supplemental calcium could also result in spaced-out feelings .That a goal of magnesium supplementation is to increase calcium absorption in the gut once again underlines that minerals to be effective must be bioavailable in the gut. Chelated magnesium supplements, for example, magnesium glycinate, are avoided.
That magnesium can affect calcium absorption is not news, however, calcium is now still very frequently the ‘go to’ ,mineral given a mineral is supplemented for the prevention and/or treatment of osteoporosis. .A search of PubMed using “calcium supplementation” and “‘osteoporosis” turned up 725 hits while a search of “magnesium supplementation” and “osteoporosis” turned up 20 hits. Taurine, vitamin D3 and vitamin K2 MK-7 would also be required to prevent and/or treat osteoporosis..