The oleic acid to stearic acid ratio and obesity

Apparently the ratio of oleic acid to stearic acid ratio is a key ratio in terms of obesity. Obese women have reduced stearic acid levels and increased stearoyl CoA desaturase activity. Higher baseline levels of oleic acid/stearic acid (OA/SA), and lower levels of stearic acid/palmitic acid (SA/PA) were associated with higher rates of metabolically healthy obese to metabolically unhealthy obese conversion. In non-obese individuals an increased oleic acid to stearic acid ratio is associated with insulin resistance.

Loss of stearoyl CoA desaturase prevents obesity. Oleic acid is synthesized from stearic acid by stearoyl–CoA desaturase.A huge search is on for inhibitors of stearoly CoA desaturase. Loss of stearoyl CoA desaturase would decrease oleic acid levels and yet there is the constant loud drumbeat from the American Heart Association that oleic acid is ‘heart healthy’ fatty acid. The results can be reconciled if the ratio of oleic acid to stearic acid is key,. The only way to safely increase oleic acid levels is to increase stearic acid levels first.

Why the focus in obesity research on stearoyl–CoA desaturase.inhibitors.as opposed to supplementation with a palmitc acid/stearic acid combination? From the viewpoint of pharmaceutical corporations a palmitc acid/stearic acid combination is utterly boring. Not a dime could be made by pharmaceutical corporations given a palmitc acid/stearic acid combination were effective in weight control. The Holy Grail of pharmaceutical corporations is patentable drugs that prevent obesity. A palmitic acid/stearic acid combination is not patentable..

I have not proven that that a palmitc acid/stearic acid combination is safe, however, there is a definite inconsistency in the desire to inhibit stearoyl–CoA desaturase.and the constant loud drumbeat that oleic acid is a heart healthy fatty acid. Given the view that saturated fatty acid synthesis is dysregulated supplementation with stearic acid alone may not be advisable. Anyone taking a palmitc acid/stearic acid combination should have a metabolic with glucose panel done and lipid levels checked which is very easy to do. A palmitic acid/stearic acid combination must be taken with vitamin B6.

If I lost some weight I would find that more than acceptable. However, the top objection I have to oils with high levels of oleic acid in that such oils are highly depressing in terms of mood. The oleic acid to stearic acid ratio could play a large role in mood.

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