Vitamin B6, palmitic acid and serine palmitoyltransferase

Supplementation with stearic acid and palmitic acid requires supplementation with vitamin B6. Vitamin B6 does not appear to play a large role in the synthesis of palmitic acid or stearic acid. Why would supplementation with vitamin B6 be required?

Serine palmitoyltransferase catalyzes the reaction palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2. Serine palmitoyltransferase is a vitamin B6 dependent enzyme. To get serine palmitoyltransferase to work both palmitic acid and vitamin B6 are required.

Serine palmitoyltransferase is a key enzyme in spingolipid synthesis Spingoliipids play key roles in signal transduction and cell recognition with sphingolipidoses, or disorders of sphingolipid metabolism, having large negative mpacts on neural tissue. Shortages of either palmitic acid or vitamin B6 could negatively affect spingoliipids. In terms of long chain saturated fatty acid supplementation with both palmitic acid and stearic acid could be required. Palmitic acid and stearic acid have to be taken with supplemental vitamin B6. Given a very high quality food grade mixture of C16 (palmitic acid) and C18 (stearic acid) is supplemented metabolic panels would have to be obtained regularly..

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.