Life expectancy among persons with schizophrenia or bipolar affective disorder

Life-expectancy was 18.7 years shorter for schizophrenic men compared to men in the general population. Corresponding numbers for schizophrenic women was 16.3 years, for bipolar men 13.6 years, and for bipolar women 12.1 years,.’ With DNA demethylating mechanisms going awry in schizophrenia, due to dysregulation of TET enzymes and JumjC domain-containing proteins, all kinds of illnesses in individuals with schizophrenia can develop shortening life spans.

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