There is no doubt that high blood levels of manganese can be neurotoxic and can cause movement disorders. Backing out of manganese toxicity can’t really be done as neurons have been killed
Yet manganese is an essential trace element. For animals, such as humans, manganese is required. Manganese is required by a range of enzymes, for example, glutamine synthetase and arginase. Divalent metal transporter 1 (DMT1) transports both iron and manganese and is regulated by iron levels. Dysregulation of iron metabolism could also dysregulate manganese metabolism.
Tea can reduce manganese levels which would suggest that manganese reacts with polyphenols. A main point of this blog is that trace minerals must be available in the gut as well as systematically. The way to take trace minerals so trace minerals are available in the gut as well as systematically is take trace minerals at bedtime away from coffee, tea and other drinks except water, away from food and away from other supplements such as vitamin C.
Supplementation with a non-chelated form of manganese could be required to treat a range of mental illnesses. Tests on manganese bloods are required and not an option if manganese is supplemented. The goal is most definitely not high blood levels of manganese but rather normal blood levels of manganese where manganese is available in the gut and liver as well as systematically.
I think non-chelated forms of iron, manganese and copper have to be supplemented at bedtime in a range of mental illnesses.. I know that if iron, manganese and copper are supplemented that tests on mineral levels are required and not an option Individuals who are heavy coffee, tea and/or soda drinkers should suspect that manganese metabolism is dysregulated.