TET2 is a tumor suppressor

There are a lot of grounds for re-regulating TET enzymes. One could be enhancing anti-tumor immunity in the treatment of cancer. Stimulating TET activity by systematic injection of its co-factor, ascorbate/vitamin C, increased chemokine and TILs, leading to enhanced anti-tumor immunity and anti-PD-L1 efficacy and extended lifespan of tumor-bearing mice.

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