Cortical thickness is negatively correlated with normalized antipsychotic dosage with first generation antipsychotics having an especially negative effect on cortical thickness. The negative effect of antipsychotics on cortical thickness provides additional grounds for using antipsychotics in the lowest feasible dosage. Individuals with schizophrenia not on antipsychotics have decreased cortical thinning compared to individuals with schizophrenia on antipsychotics.. Cortical thicknesseffect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. See also Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders. Antipsychotics are flat out toxic to brains.
Lack of insight or lack of awareness of illness in schizophrenia is termed anosognosia with some 30% of individuals with schizophrenia having anosognosia.
What is the cardinal feature of anosognosia? The cardinal feature is not elaborate delusions rather the cardinal feature of anosognosia is confusion and disorganization. Individuals with agonosgnosia are having terrible cognitive difficulties.
Se-methylselenocysteine treats cognitive symptoms of schizophrenia. Supplemental Se-methylselenocysteine could be a treatment for anosognosia. Se-methylselenocysteine would be taken with iodide from kelp. Sadness can pop up in almost any illness and everywhere depression as sadness pops could be due to dysregulation of iodide transporters. Sadness in all depressions could be treated by iodide from kelp, l-tyrosine and Se-methylselenocysteine. L-tyrosine is involved in the synthesis of thyroid hormones. Patients might not be responsive to treatment for anosognosia with Se-methylselenocysteine if they are intensely sad..
Iodide from kelp, L-tyrosine and Se-methylselenocysteine would not treat all states associated with depression only sadness. Kelp and L-tyrosine have to be taken three or four times a day. Thyroid tests must be obtained. The goal is most definitely not high thyroid hormone levels. Iodide from potassium iodide apparently reacts with too many substances. The effect of iodide from potassium iodide is not dependable. Approximately 1000 micrograms of iodide from kelp have to be taken each dosage. Iodide from kelp and L-tyrosine are taken three times a day . L-tyrosine taken without iodide is not helpful. L-tyrosine and kelp are taken away from food.
Se-methylselenocysteine is supplemented. Selenium is also required for thyroid hormone homeostasis. 200 micrograms of Se-methylselenocysteine is taken once a day. More Se-methylselenocysteine is not better. Deiodinases, which are selenoproteins, can both activate and deactivate thyroid hormones. Selenium taken alone could stress the thyroid.
sT4 – active, T3 very active, rT3 not active, ID1 – deiodinase I, ID2 – deiodinase II, IDIII – deiodinase III.
Patients on Se-methylselenocysteine, iodide from kelp and L-tyrosine could have ahedonia but there would be an awareness of illnesses. More organized delusions though with an awareness of illness could be a feature of the treatment. I hold more can be done to treat schizophrenia, however, Se-methylselenocysteine, iodide from kelp and l-tyrosine can readily tested as a treatment for agonosgnosia.
Yet the key selling point of most mineral supplements is increased absorption with increased absorption demanding that the gut be bypassed. Moreover almost all clinical studies done on humans employ inorganic forms of minerals rather than chelated organic forms of minerals. ‘Zinc gluconate human‘ turned up 560 results in Pubmed whereas ‘zinc methionine human, turned up 11 results where there were two human trials with an equivocal result in one of the trials and a positive result on a narrow measure of reduced acne in the other.
Individuals taking organic chelated mineral supplements are venturing into unknown lands and I think dangerous lands. Chelated minerals are highly absorbed but that is a bug not a feature.