A unitary theory of sadness in all depressions

The thyroid may still yet have large undiscovered lands. There are many ways that individuals can feel below par.. Sadness in depressions is different than malaise, fatigue are lethargy though malaise, fatigue and lethargy are very frequently associated with depression.

Sadness in all depressions could be due to dysregulation of iodide transporters. Thyroid hormone levels can be normal while thyroid hormone homeostasis can be upset resulting in sadness though thyroid tests show patients as apparently euthyroid. In all instances of intense sadness iodide transporters could be dysregulated even intense sadness due to mourning.. A reasonable period of mourning would, of course, not call for pharmaceutical treatment.

There is an upside to this and a downside to this. Sadness is all depressions except due to mourning, could be highly pharmaceutically treatable. Sadness can pop up in almost any illness and everywhere depression as sadness pops could be due to dysregulation of iodide transporters. Sadness in all depressions could be treated by iodide from kelp, l-tyrosine and Se-methylselenocysteine. Iodide from kelp, L-tyrosine and Se-methylselenocysteine would not treat all states associated with depression only sadness. Kelp and L-tyrosine have to be taken three or four times a day. Thyroid tests must be obtained. The goal is most definitely not high thyroid hormone levels. Iodide from potassium iodide apparently reacts with too many substances. The effect of iodide from potassium iodide is not dependable. Approximately 1000 micrograms of iodide from kelp have to be taken each dosage. Iodide from kelp and L-tyrosine are taken three times a day . L-tyrosine taken without iodide is not helpful. L-tyrosine is taken on an empty stomach. Se-methylselenocysteine is supplemented. Selenium is required for thyroid hormone homeostasis. 200 micrograms of Se-methylselenocysteine is taken once a day. More Se-methylselenocysteine is not better.

The downside of this is that iodide from kelp, L-tyrosine and Se-methylselenocysteine would only treat sadness. Individuals could still feel way below par even though their intense sadness had been addressed . The SMVT besides transporting iodide also transports biotin, lipoate and pantothenic acid.. Supplemental iodide would not necessarily re-regulate the SMVT. At this point treatment becomes much more complex. Under no grounds should lipoic acid ever be supplemented as lipoate is synthesized on residues and supplemental lipoic acid would only block the SMVT. Iodide from kelp, L-tyrosine and Se-methylselenocysteine can do a lot but far from everything.

Selenium and the thyroid gland

l thyroid gland

The human thyroid gland has the highest selenium content per gram of tissue among all organs.The iodothyronine deiodinases (DIO1,2,3), are selenoproteins. Glutathione peroxidase and thioredoxin reductase are selenoproteins that are involved in protection of the thyroid from hydrogen peroxide.

The first step in the synthesis of thyroid hormones is catalyzed by thyroid peroxidase which requires hydrogen peroxide. Hydrogen peroxide used by thyroid peroxidase is produced by dual oxidase 1 and dual oxidase 2. Hydrogen peroxide is both required for thyroid hormone synthesis but also can be toxic to the thyroid gland. Selenium is required both for thyroid hormone synthesis and protection of the thyroid from hydrogen peroxide needed to synthesize thyroid hormones. .

Biohack mental illness now!

l CRISPR DIY kit not required

A lot of biohacking does not appear to be safe. For example, trying to alter at home one’s genetic makeup via CRISPR seems beyond unsafe.

A lot of biohacking is undertaken to achieve increased longevity. Biohacking for increase longevity requires that one wait around for decades to see the results. One has to wait 30 or 40 years to see whether one selected a right mix of supplements and then in all probability if one lives to a healthy 100 years of age one would not know exactly which supplements were the key supplements. Knowledge as to what increases longevity would still be lacking. One could be interviewed with questions asked as to how longevity was achieved and a laundry list of supplements would then be detailed. Someone listening to the interview could say, ‘I will eat 3 strips of bacon every morning. The other guy eats three strips of bacon every morning and is an alert, healthy 102 year old.’

A lot of specialty nootropics taken for cognitive enhancement have unclear effects and have not been widely tested in clinical trials . Moreover most nootropics are likely manufactured in China which does not have a reputation for tight controls on drug manufacture. What is more there would be a huge mainstream market for nootropics given noontropics worked. Individuals with mental illnesses very frequently could use some cognitive enhancement but nootropics are not being prescribed. After decades of use and study use of nootropics appears to be a very sketchy practice.

The appeal now of becoming part cyborg is 98% aesthetic. Becoming part cyborg now does not result in cognitive enhancements or health enhancements.

Biohacking mental illness

I hold that a lot of mental illness can be biohacked now, this week. 600 milligrams of carbonyl iron taken once a day at bedtime can treat psychosis. 200 micrograms of Se-methylselenocysteine taken once a day in the morning. can treat disorganization. 1,000 micrograms of iodide from kelp taken three times a day with 1000 milligrams of L-tyrosine taken three times a day can treat depression which is presents as sadness. Iron interacts with lots of substances, coffee and tea being two examples. The point of taking the carbonyl iron at bedtime is to take the iron and iodide away from substances that can interfere with iron metabolism in the gut. The last cup of coffee or cup of tea of the day should be drunk at least 6 or 7 hours before carbonyl iron is taken.

300 milligrams of thiamine is taken 4 times a day can decrease fatigue.

No other supplements would be taken.


I hold that iron-sulfur proteins are dysregulated in schizophrenia and that 600 milligrams of carbonyl iron taken once a day at bedtime can address the psychosis of schizophrenia. There is no direct clinical evidence that iron-sulfur proteins are dysregulated in schizophrenia. Given iron-sulfur proteins were dysregulated in schizophrenia this would cause major difficulties where psychosis could be one such difficulty.

There is no clinical evidence Se-methylselenocysteine effectively treats cognitive symptoms of schizophrenia.

Everyone who is treated for depression has had their thyroid hormone levels checked. A search of PubMed using ‘thyroid major depressive disorder’ turns up 999 articles. Thyroid hormones have not proven efficacious in treating major depressive disorder. Yet I hold that major depressive disorder is partly due to thyroid dysregulation. Conceivably doctors when prescribing T3 never asked the correct question. The correct question would be ‘Are you still sad?’ Not ‘Has your depression remitted?’

Why such high dosages of thiamine are needed is not clear. 25 milligrams of vitamin B6 twice a day. could also be helpful.

T4 could work better than iodide and L-tyrosine. T4 is fully iodinated and with T4 one would still be working with natural mechanisms for the production of T3 ,which is the active hormone. T3 could be too much. With T4 the question to ask would be ‘has the sadness passed? not ‘has the depression remitted?’


No other supplements should be taken.

Iodide from kelp and L-tyrosine only treats depression as sadness. Frequently malaise and apathy are associated with major depressive disorder which iodide and L-tyrosine would likely not address. Iodide and L-tyrosine are not going to address all symptoms of major depressive disorder.


Dirt simple and very quick. Very safe for at least a week. If the treatment has not worked at the end of week the treatment would be stopped. If the treatment is effective then safety of the supplements can be studied further and necessary tests obtained.

A lot of research cited on this website points to iron-sulfur cluster formation and selenoprotein metabolism being dysregulated in various neurological illnesses. Dysregulation of thyroid hormones can certainly result in depressive illnesses.