All books that address the history of scientific research on the brain have sections on phrenology. The upshot of book sections on phrenology is that phrenology was the dark ages of brain research. A lot of phrenology was nonsense. But is there a kernel of truth to phrenology? I have been claiming that the negative symptoms of schizophrenia are due to brains being compressed due to hidden osteomalacia arising from dysregulation of calcium homeostasis due to deficiencies in taurine.
Wolfgang Pauli once said ‘the idea is so bad it is neither right or wrong‘. My idea could be wrong. I am not quite certain what imagining techniques are used to detect osteomalacia but the evidence may right now be stored in data banks. Currently skulls are stripped from MRI images. A search of PubMed using the search terms “osteomalacia” and “schizophrenia” turned up three articles which were irrelevant. There is apparently a reduction in brain volumes in schizophrenia which could be due to skulls being compressed due to hidden osteomalacias.
So far brain imaging has only discovered that individuals with brain structures that are all in the normal range of sizes can have schizophrenia. Still brain imaging or at least skull imaging could could be a key to treatment of the negative symptoms of schizophrenia which can be devastating.