Supplementing with free antioxidants in more than RDA amounts is worse than useless

Many illnesses, such as schizophrenia, Alzheimer’s disease, Parkinson’s disease and bipolar disorder are associated with oxidant stress. Yet, increasing levels of free antioxidants by supplementing with more than RDA amounts of vitamin E, beta-carotene and vitamin C does not treat these illnesses.

Increasing levels of free antioxidants via supplmentation could be much worse than useless. Before iron can be absorbed iron must be reduced from Fe3+ to Fe2+. Antioxidants like vitamin C, vitamin E , beta-carotene and quercetin could one way or other promote the reduction of Fe3+ to Fe2+ in the gastrointestinal tract which would increase absorption. The goal, however, is to delay iron absorption as long as feasible.

There is oxidant stress in lots of illnesses but this could be due to dysregulation of selenoproteins and dysregulation of iron metabolism which would not be fixed by increasing levels of free antioxidants with supplemental vitamin C, vitamin E , beta-carotene, quercetin etc.

Supplementing with free antioxidants could be associated with very subtle but serious mineral dysregulations which would basically be undiagnosable.

Taking supplements

If someone is healthy not taking supplements and eating balanced meals is an excellent health strategy.  There are lots of pitfalls with supplements. The worst way to take supplements is to follow the scientific evidence but disregard fails in clinical trials. If there is lots of scientific research in an area but  clinical trials have not panned out there are very serious unknown factors that make such a strategy a dangerous strategy. Take for example, antioxidants. There is tons of scientific evidence that oxidant stress is a major difficulty in many illnesses but clinical trials of antioxidants have not shown supplemental free antioxidants to be useful in the treatment of  chronic illnesses.   Antioxidants should work but don’t work adds up to don’t try at home what has been shown to be a fail in clinics.   Supplemental folic acid can be dangerous. Folic acid is another supplement that should work but clinical trials have not shown supplemental folic acid to be helpful where there are high homocysteine levels though, of course, women should take folic acid as MDs recommend to prevent neural tube defects in babies.  My ideas adhere to scientific evidence, however, my ideas have not been clinically proven wrong.