A simple experiment that can be done at home

If an individual has a mental illness that individual should try drinking only water for a month and check at the end of the month whether there has been an amelioration of his or her mental illness. Food can, of course, be eaten but preferably foods without natural flavors. In the gut iron must be uncomplexed with polyphenols or with compounds that increase iron absorption. Both polyphenols which decrease iron absorption and acids, such as citric acid, that increase iron absorption must be avoided. Vitamin C supplements should be avoided. If an individual takes a few drinks of drinks other than water an intense unease could result and that individual will be inclined to try a ‘hair of the dog’ remedy which will just greatly worsen mood. Some unease while drinking only water could come from eating foods with natural flavors. Upon reading frozen food labels what goes into frozen foods frequently seems almost perfectly senseless. One or two 100 mg pills of caffeine taken a day should be okay. Even if an individual does not have a mental illness drinking only water should be tried for a month to see if there are enhancements in mood.

Extraordinary claims require extraordinary proofs. In practice extraordinary proofs should be readily obtainable. Drinking only water for month can easily be done.

Why would humans be so sensitive to polyphenols? In small amounts polyphenols can have large though subtle effects on mood. In small amounts for example the amounts in fresh unprocessed fruits and vegetables polyphenols can have very positive affects on mood. Nature arranged matters so humans would get kicks from eating fruits and vegetables. With sodas, coffee and tea humans have lost their liking for fruits and vegetables and now just prefer junk food.

Only water was drunk in Paleolithic times. Herbal tea is allowed on current Paleolithic diets however in the Paleolithic after a day of hunting mastodons herbal tea was not drunk around campfires. The apparent safety of herbal tea is very deceptive. Herbal tea is very high in polyphenols.

Positive results should be present in two or three days. There should be some fresh fruits and/or vegetables available to address cravings for polyphenols.

Coffee and homocysteine

Filtered or unfiltered coffee increases homocysteine levels in healthy individuals whereas caffeine has a much weaker effect on homocysteine levels. Stopping drinking coffee reduces homocysteine levels.

Increased homocysteine levels point to decreased levels of L-cysteine which is synthesized from homocysteine. With decreased synthesis of L-cysteine iron-sulfur cluster formation could be dysregulated which could upset many biological processes. Increased homocysteine levels could could affect DNA methylation. In schizophrenia there is a positive association between plasma homocysteine and DNA methylation. Difficulties due to coffee could take years to develop due to hypermethylation of genes taking years to develop.