Branched-chain amino acid degradation, beta-oxidation and biotin

On this blog I have argued that the sodium-dependent multivitamin transporter (SMVT) is dysregulated in bipolar depression. . The SMVT transports biotin. Biotin-dependent enzymes, methylcrotonoyl-CoA carboxylase and propionyl-CoA carboxylase are involved in the degradation of branched-chain amino acids.. Methylcrotonoyl-CoA carboxylase and propionyl-CoA carboxylase in the branched-chain amino acid pathway are very closely associated with enzymes that are also involved in beta-oxidation.

Enoyl-CoA hydratase is involved in both the degradation of branched-chain amino acids and beta-oxidation. 3-hydroxyacyl-CoA dehydrogenase is involved in both the degradation of branched-chain amino acids and beta-oxidation. Acetyl-CoA acyltransferase is involved in both the degradation of branched-chain amino acids and beta-oxidation. Acyl-Coenzyme A dehydrogenase is an enzyme involved in both the degradation of branched-chain amino acids and beta-oxidation. These four enzymes are one on two enzymes away from biotin-dependent enzymes in the branched-chain amino acid degradation pathway.

The upshot of this in that dysregulation of biotin-dependent enzymes in the branched-chain amino acid degradation pathway will also dysregulate the beta-oxidation pathway. In conjunction with other supplements olive oil, which will increase beta-oxidation, can be a helpful supplement.