chewing betel nut
Nicotine is one of the most addictive substances on Earth. Nicotine agonizes nicotinic acetylcholine receptors which are a different kind of acetylcholine receptor than muscarinic acetylcholine receptors. Muscarinic agonists may have no addictive potential and may in fact be drugs that can treat addictions. However, betel nut which activates muscarinic receptors is very addictive . Before mucarinic agonists are generally prescribed any addiction potential of muscarninic agonists has to be thoroughly addressed.