In previous posts I held that biotin and pantothenic are helpful in the treatment of negative symptoms of schizophrenia and the two supplements are. I have not, however, stressed the role biotin and coenzyme A, which is synthesized from pantothenic acid, play in the synthesis and metabolism of non-essential fatty acids. Fatty acid synthesis and fatty acid metabolism require coenzyme A and biotin. Acetyl-CoA carboxylase catalyzes the rate limiting step in the synthesis of fatty acids. Acetyl-CoA carboxylase requires CoA and biotin.
Biotin and pantothenic acid work a lot better for negative symptom of schizophrenia if intake of animal fats is increased concurrently. Low levels of biotin would adversely affect the synthesis and metabolism of non-essential fatty acids. Fatty acids derived from essential fatty acids would not be affected by low levels of biotin.
In terms of what non-essential fatty acids to supplement with animal fatty acids are basically the only route to go. Non-essential fatty acids from plants will have high levels of polyphenols and the mix of non-essential fatty acids from meat is a better non-essential fatty acid mix than can be obtained from various plants.
I have heavily stressed adverse affects of polyphenols. I have focused on decreases in iron absorption that can result from polyphenols. Polyphenols, however, can also increase beta-oxidation. Increasing beta-oxidation results in huge difficulties if there are difficulties in fatty acid synthesis and metabolism. Individuals who have difficulties synthesizing and metabolizing non-essential fatty acids will be adversely affected by high intakes of polyphenols.
Intakes of animal fatty acids must be increased for full effectiveness of biotin and pantothenic acid in the treatment of the negative symptoms of schizophrenia. See the Treatment page on what more would be required.
Recommendations against saturated fats by the American Heart Association could have had disastrous effects on the mental and neurological health of tens of millions of individuals. There is the likelihood that Warren Buffett would be a poor unhappy man now if he had followed the dietary recommendations of the American Heart Association.