Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly.
Alehagen U, Aaseth J, Alexander J, Johansson P.
The following quote is from the paper.
“Conclusion: This is a 12-year follow-up of a group of healthy elderly participants that were supplemented with selenium and coenzyme Q10 for four years. Even after twelve years we observed a significantly reduced risk for CV mortality in this group, as well as in subgroups of patients with diabetes, hypertension, ischemic heart disease or impaired functional capacity. The results thus validate the results obtained in the 10-year evaluation. The protective action was not confined to the intervention period, but persisted during the follow-up period. The mechanisms behind this effect remain to be fully elucidated, although various effects on cardiac function, oxidative stress, fibrosis and inflammation have previously been identified. Since this was a small study, the observations should be regarded as hypothesis-generating.”
Coenzyme Q10 is a co-factor for succinate dehydrogenase. Succinate dehydrogenase metabolizes succinate in the TCA cycle. Succinate inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes. By way of being a co-factor for succinate dehydrogenase coenzyme Q10 could reduce inappropriate DNA and histone methlylation decreasing mortality. Ubiquinol should not be helpful in terms of decreasing mortality.
TET enzymes, which demethylate DNA, are 2-oxoglutarate dependent enzymes. 2-oxoglutarate is synthesized by the citric acid cycle. Mutation of genes for enzymes in the citric acid cycle can inhibit TET enzymes, thereby dysregulating epigenetic mechanisms.
There are infectious diseases subdivided into bacterial and viral diseases, there is cancer where there are many sorts of cancer, there is heart disease, lung disorders etc. There could be a new disease class. There could be epigenetic disorders where there is common origin for a wide range of epigenetic disorders. With epigenetic mechanisms dysregulated many different diseases can arise as there are many different ways genes and histones can become inappropriately methylated. My idea is that a dysregulation of aconitase 1 can dysregulate iron metabolism and decrease 2-oxogularate synthesis which will in turn dysregulate TET enzymes, which demethylate DNA, and dysregulate Jumonji domain-containing proteins, which demethylate histones. Dysregulation of TET enzymes and dysregulation of Jumonji domain-containing proteins can play out many different ways in terms of inappropriate DNA methylation and inappropriate histone methylation whereby many different diseases can arise. Though many different diseases can arise from dysregulations of aconitase 1, iron metabolism and 2-oxoglutarate synthesis prevention of a range of illnesses could be achieved by the same treatment. For example, a treatment than prevents schizophrenia could also prevent Alzheimer’s disease and Parkinson’s disease. The Treatment presented in the Treatment section is not ready for home use, however, a Moon shot would not be necessary to get the treatment to a state where family doctors could prescribe a treatment which would prevent a range of chronic illnesses from schizophrenia, to Alzheimer’s disease, to Parkinson’s disease. What is needed is a launch ten weather balloons into the high atmosphere then collect and analyze data kind of effort.